01 - Preheat oven to 425°F. Line a large baking sheet with parchment paper.
02 - Toss cauliflower florets with olive oil, salt, and pepper. Arrange in a single layer on the prepared baking sheet.
03 - Roast for 25–30 minutes, flipping halfway through, until florets are golden brown and tender with crispy edges.
04 - While cauliflower roasts, whisk together mayonnaise, sour cream, chili powder, smoked paprika, garlic powder, and lime juice in a large bowl until smooth.
05 - Transfer hot cauliflower to the bowl with sauce. Toss vigorously until thoroughly coated.
06 - Add half the cotija cheese, half the cilantro, red onion, and jalapeño. Toss to distribute evenly.
07 - Transfer to a serving platter. Sprinkle with remaining cotija, additional chili powder, and cilantro. Serve warm with lime wedges.